Skip to main content


PEPSE stands for post-exposure prophylaxis after sexual exposure to HIV.

If you’ve had unprotected sex - sex without a condom or you have used a condom and it broke - with somebody who you think might be HIV positive within the last 72 hours you may be able to avoid infection by taking PEPSE. This medicine must be taken within 72 hours of the potential contact with HIV to be effective.

If it is Monday-Friday and our Sexual Health Clinic at St Catherine's Health Centre is open please attend immediately for an emergency slot. Please note PEP is not available at Brook, Eastham, Victoria Central Hospital or Arrowe Park Hospital Sexual Health Clinics. If the St Catherine’s HC clinic is closed, or you would prefer,  please attend your nearest Accident and Emergency department as soon as possible and within the 72 hours for Post Exposure Prophlyaxis. If you are a Wirral resident then this would be Arrowe Park Hospital, Upton, Wirral, CH49 5PE.

It is vital that this medication is given within 72 hours of the potential exposure to the virus, as the medication is not effective after this time. The earlier PEPSE can be given the better, do not leave it until the 72 hours is up or nearly up.

A&E will only be able to give you your initial start dose. You will then need to contact our service to arrange a follow up appointment - this will include further medication and monitoring. To book your follow up appointment you will need to call the team on 0300 123 5474.